A publication in Pharmaceutical Research, an official journal of @AAPS, titled “Intradermal Vaccination with PLGA Nanoparticles via Dissolving Microneedles and Classical Injection Needles”, featured the use of the uPATCH applicator to assess the penetration efficiency and dissolution behavior of dissolvable microneedle arrays (dMNAs).
Following the initial selection of a promising dMNA formulation, skin penetration and dissolution studies were performed using the uPATCH applicator. Based on these results, which demonstrated poor MN dissolution (Fig. 4a-c), the formulation ratios were optimized to improve microneedle performance and thereby drug delivery (Fig. 4d-e). In addition, these evaluations play a key role in refining drug loading strategies.
We are proud to see the uPATCH technology contributing to scientific research and supporting the advancement in intradermal drug delivery systems!
The research was conducted by researchers from the Leiden Academic Centre for Drug Research at Leiden University, in collaboration with the Tyndall National Institute.
DOI: 10.1007/s11095-024-03665-7
